Biography
Research
Faculty
Xiaoxin Luke Chen, MD, PhD
Professor of Surgery
Director, Surgical Research
Education and Training
| Medical School: | MD, Peking University Health Sciences Center, Beijing, China |
| Graduate School: | PhD, Biochemistry, Rutgers, The State University of New Jersey |
| Residency: | Orthopaedic Surgery, People's Hospital, Peking University Health Sciences Center, Beijing, China |
Special Research Interests
- Molecular mechanisms and targeted therapy of Nrf2Mut-esophageal squamous cell carcinoma (ESCC): The goal is to understand how Nrf2 mutation contributes to ESCC and to develop inhibitors of Nrf2 or its downstream kinases for targeted therapy.
- Molecular mechanisms and chemoprevention of alcohol-associated ESCC: We focus on the roles of Notch-Pax9 signaling and Nrf2-Acss2 axis-mediated metabolism in alcohol-associated carcinogenesis. Our long-term goal is to develop “benign cell boosters” (Nrf2 activators, Notch activators) as chemopreventive agents based on the concept of cell competition
Awards and Honors
- AACR Minority-Serving Institution Faculty Scholar in Cancer Research (2007)
- AACR Young Investigator Award, American Association for Cancer Research (1999)